Can the 'Love Hormone' Oxytocin Alleviate Mood Swings in Women Experiencing Sleep Disruption?

Synopsis
Key Takeaways
- Oxytocin may protect against mood disturbances linked to sleep loss.
- Higher oxytocin levels correlate with reduced mood issues following sleep disruption.
- Sleep interruptions can significantly impact emotional health.
- Women often face hormonal changes that affect sleep and mood.
- Understanding oxytocin could improve mental health support during reproductive transitions.
San Francisco, July 13 (NationPress) Oxytocin, often termed the 'love hormone', may serve as a protective factor against mood fluctuations resulting from sleep deprivation and hormonal changes during significant reproductive phases such as postpartum and menopause, according to research findings.
A team from Brigham and Women’s Hospital and Harvard Medical School investigated the combined effects of sleep disruption and estrogen reduction on mood and oxytocin levels in healthy premenopausal women.
Their research indicates that oxytocin could mitigate the adverse mood impacts associated with fragmented sleep, which is frequently overlooked during reproductive transitions.
“Our research revealed that oxytocin levels increase in response to stress-related sleep disruption, and women exhibiting higher oxytocin levels prior to sleep disruption reported less mood disturbance the subsequent day,” stated Irene Gonsalvez, an associate psychiatrist at Brigham and Women’s Hospital and instructor at Harvard Medical School in Boston.
These findings highlight oxytocin's role as a potential biological safeguard during times of hormonal and emotional instability.
Many women experience sleep disturbances during postpartum and menopausal phases, which are linked to significant hormonal changes.
However, such disturbances are often downplayed as mere inconveniences. This study offers new biological evidence that sleep interruptions can be connected to significant emotional health changes, suggesting that oxytocin may act as a crucial protective element.
In the research, 38 healthy premenopausal women participated in two 5-night inpatient protocols: one during a natural hormonal state and the other after estradiol suppression. After two nights of uninterrupted sleep, the researchers simulated disrupted sleep patterns akin to those commonly experienced during postpartum and menopause for three nights. Mood disturbances and oxytocin levels were monitored throughout the study.
The results indicated that sleep disruption significantly heightened both mood disturbances and oxytocin levels, with higher oxytocin levels prior to sleep disruption correlating with reduced mood disturbances the following day. Increased instances of mood disturbances linked to sleep disruptions were also associated with elevated oxytocin levels the next day.
“Millions of women encounter mood-related symptoms during reproductive transitions, yet treatments frequently concentrate primarily on antidepressants or hormone therapy,” Gonsalvez mentioned. “Recognizing oxytocin’s potential as a natural mood stabilizer could enhance our ability to support women’s mental health during these crucial phases.”
The findings were presented at ‘ENDO 2025’, the annual meeting of the Endocrine Society held in San Francisco.