What Deadly Secrets Does the Black Scorpion Sting Hold?

Synopsis
Key Takeaways
- The black scorpion's sting injects 25 distinct toxins.
- These toxins can severely damage the liver and immune system.
- The study provides crucial insights into a lesser-known species.
- Research could lead to better management of scorpion venom.
- Understanding these toxins is vital for public health.
New Delhi, Aug 6 (NationPress) Researchers from the Institute of Advanced Study in Science and Technology (IASST) in Guwahati, an autonomous body under the Department of Science and Technology (DST), have discovered that the sting of the black scorpion injects 25 unique deadly toxins capable of inflicting serious harm to the liver and the immune system.
Due to its high level of mortality and morbidity, the sting of the glossy black scorpion, primarily found in the forests of Eastern and Southern India, represents a significant global health issue.
“The peril associated with the sting stems from the 25 distinct toxins across eight different protein families contained in the venom,” stated the research, led by Prof. Ashis K. Mukherjee, Director of IASST, alongside research scholar Susmita Nath.
Despite its prevalence and serious implications, this species has received limited scientific examination, resulting in a poor understanding of its venom's composition, toxicity mechanisms, and biological relevance.
To gain insights, the research team conducted an extensive analysis of the venom profile of Heterometrus bengalensis (HB), a relatively under-studied species native to the eastern and southern regions of India.
Utilizing spectrometry and biochemical assessments, the team identified the 25 key toxins from 8 protein families present in HB venom.
Through experiments on Swiss albino mice, they found that the venom resulted in systemic toxicity, elevated liver enzymes, organ damage, and a significant pro-inflammatory response.
“Once the venom infiltrated the mice’s systems, it induced a systemic toxic storm. Liver enzyme levels surged, indicating hepatic distress. Signs of organ damage emerged, and most alarmingly, the immune system went into overdrive, triggering a pro-inflammatory response that suggested potential shock or severe allergic reactions in actual stings,” noted the researchers.
This study, published in the International Journal of Biological Macromolecules, fills a critical gap in scorpion research by focusing on a lesser-known species and lays the groundwork for future studies on venom and its management.