Israeli Researchers Explore New Therapy for Canine Chronic Kidney Disease
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Synopsis
Israeli researchers have tested a new treatment for chronic kidney disease (CKD) in dogs, focusing on the effects of paricalcitol, a synthetic vitamin D. The study indicates potential benefits in stabilizing kidney function in affected dogs, offering hope for improved management of this progressive condition.
Key Takeaways
- Research conducted in Jerusalem focuses on CKD in dogs.
- Paricalcitol showed promise in stabilizing protein levels.
- Kidney disease is progressive and affects older and younger dogs alike.
- Early diagnosis and management can enhance quality of life.
- Further studies are needed for long-term effectiveness.
Jerusalem, March 21 (NationPress) Researchers in Israel have investigated a promising therapy for chronic kidney disease (CKD) in dogs. The findings, published in the Journal of Veterinary Internal Medicine, assessed the impact of paricalcitol, a synthetic version of vitamin D, as reported by the Xinhua news agency.
The research team from Hebrew University of Jerusalem focused on two prevalent CKD complications: renal secondary hyperparathyroidism (RHPT) and proteinuria, which is the presence of excess protein in urine.
CKD is a progressive illness that can lead to kidney failure, affecting mainly older dogs, but it can also appear in younger ones.
RHPT arises when compromised kidneys cannot effectively regulate minerals such as calcium and phosphorus, resulting in elevated levels of parathyroid hormone (PTH) that may weaken bones and damage organs.
The trial involved 13 dogs diagnosed with CKD, who received either paricalcitol or a placebo over two separate 12-week phases.
Results showed that proteinuria deteriorated in dogs given a placebo, whereas it remained stable in those treated with paricalcitol, indicating that this drug might aid in preserving kidney function.
Some dogs receiving treatment saw minor increases in calcium levels, but adjustments in dosage managed this condition effectively.
While these results are promising, additional research is essential to evaluate the long-term safety and efficacy of this treatment.
CKD in dogs, also referred to as chronic renal failure, is a progressive disorder where kidneys gradually lose functionality, leading to various symptoms such as increased thirst and urination, vomiting, and weight loss.
Typical symptoms include heightened thirst, frequent urination, reduced appetite, weight loss, vomiting, and decreased energy levels.
In the initial stages of CKD, symptoms may not be evident as the kidneys can still function adequately. Aging and kidney infections are the most common causes of CKD in dogs.
Although the condition is progressive and currently incurable, early diagnosis and appropriate management can significantly enhance a dog's quality of life and longevity.
