Could INST Researchers Have Found a Non-Invasive Way to Stimulate Brain Cells?

Synopsis
Key Takeaways
- Graphitic carbon nitride can stimulate brain cells naturally.
- This material could open new therapeutic paths for neurodegenerative diseases.
- It generates electric fields to enhance neuron growth and communication.
- This biocompatible nanomaterial offers a non-invasive therapy.
- Further studies are needed before human applications can begin.
New Delhi, Sep 24 (NationPress) Researchers at the Institute of Nano Science and Technology (INST), an autonomous body under the Department of Science and Technology (DST), have created an innovative nanomaterial capable of communicating with neurons in a natural manner.
This groundbreaking finding could revolutionize the treatment of brain disorders, according to the research team.
The nanomaterial, known as graphitic carbon nitride (g-C₃N₄), is able to stimulate brain cells without the necessity for electrodes, lasers, or magnets.
As reported in the journal ACS Applied Materials and Interfaces, the study reveals that graphitic carbon nitride enhances the growth, maturity, and communication of neurons by harnessing the brain's own electrical signals.
“This marks the first instance of semiconducting nanomaterials directly influencing neurons without external stimuli,” stated Dr. Manish Singh, who led the research at INST.
“This discovery opens new therapeutic pathways for neurodegenerative conditions like Parkinson's and Alzheimer's, ” Singh emphasized.
The material has also been shown to increase dopamine production in lab-grown brain-like cells and decrease toxic proteins associated with Parkinson's disease in animal studies.
Current treatments such as deep brain stimulation (DBS) typically involve surgical implants, while alternatives utilize magnetic or ultrasound waves to target brain tissue. Although effective, these methods can be invasive or limited.
In contrast, graphitic carbon nitride can naturally communicate with neurons.
When positioned near nerve cells, it generates minute electric fields in response to the brain's voltage signals. These fields open calcium channels in neurons, promoting growth and enhancing cellular connections without the need for any external devices.
This material functions like a smart switch, adapting to the resting and active states of neurons, thereby fostering optimal conditions for healthy brain function.
This biocompatible nanomaterial, with its potential to stimulate brain cells and reduce disease-related proteins, presents a promising non-invasive treatment option for millions.
The advancement could also influence future technologies such as “brainware computing.”
Researchers globally are exploring brain organoids—tiny lab-cultivated brain tissues—as biological processors. Integrating them with semiconducting nanomaterials like g-C₃N₄ could enhance the efficiency of these living computers, paving the way for new innovations in bio-inspired computing.
The scientists noted that extensive preclinical and clinical trials are necessary before human application.
“We believe this signifies a remarkable shift in neuromodulation research. From treating brain injuries to addressing neurodegeneration, semiconducting nanomaterials hold vast potential for the future,” Dr. Singh concluded.