Hollywood actor John Stamos has opened up about the rocky start to his relationship with the late comedian Bob Saget, revealing that the two did not get along for the first couple of years on the set of Full House — before a series of family tragedies drew the cast together as brothers.

The Initial Friction on Set

Stamos, 62, shared the candid account during an appearance on 'Bobby Bones Presents: The Bobbycast', recounting how his expectations heading into Full House differed sharply from the atmosphere he encountered. Having previously worked alongside veteran sitcom actor Jack Klugman, Stamos arrived on set with what he described as 'an actor's point of view' — focused on crafting scenes with intention.

What he found instead was a set culture centred on getting laughs from the crew. 'All they really cared about was making the crew laugh,' Stamos said. 'I was coming to it with more of an actor's point of view of these scenes and trying to work these scenes. And the guys were just trying to make the guys, the crew, laugh and whatever that was about.'

Why Stamos Was Drawn to the Cast

Despite the early friction, Stamos said he had been genuinely excited to work alongside both Saget and co-star Dave Coulier, given their backgrounds in stand-up comedy. 'I love stand-up comedy. I'm obsessed with stand-up comedy,' he said. He elaborated: 'I try to befriend any great comic out there. I can't do it, but I'm fascinated by the structure, how you guys construct a joke, the science, the math behind the economy of words. I'm just fascinated by it. So getting to work with those guys was incredible from that standpoint.'

The Turning Point: Three Brothers, Three Sisters

The tension between Stamos and Saget eventually gave way to a deep bond — forged not by professional success, but by shared personal anguish during the show's third year. 'Bob's sister got scleroderma, which he spent the rest of his life advocating and raising money for this horrific disease. Dave's sister got cancer, and my sister was diagnosed with a brain tumor,' Stamos recounted. 'And so all of a sudden, we weren't three guys on a show. We were three brothers grieving our sisters.'

The account underscores how the public warmth that Full House projected on screen was eventually mirrored — though painfully — by genuine emotional bonds forged off it.

Remembering Bob Saget

Bob Saget was found dead on 9 January at the age of 65 in his hotel room at The Ritz-Carlton Orlando, Grande Lakes in Florida. His passing prompted an outpouring of tributes from across the entertainment world, with Stamos among those most publicly devastated by the loss. Saget had remained a vocal advocate for scleroderma research throughout his life, a cause made personal by his sister's illness.

Stamos's latest reflections add a layer of complexity to the Full House legacy — one that began with professional clashes but ultimately became one of television's most enduring off-screen friendships.