What Are the Eight New Genes Linked to Schizophrenia?
Click to start listening
Synopsis
UK researchers have made a groundbreaking discovery by identifying eight new genes associated with schizophrenia, paving the way for better understanding and treatment of this complicated mental disorder. This remarkable finding could transform how we approach schizophrenia in the future.
Key Takeaways
- Identification of eight new genes linked to schizophrenia.
- Study reveals genetic connections to other neurodevelopmental disorders.
- Research indicates the role of DNA organization and neurotransmitter communication.
- Hope for future therapies based on genetic findings.
- Essential collaboration among international researchers.
New Delhi, Aug 16 (NationPress) Researchers in the UK have identified eight novel genes linked to schizophrenia, marking a significant advancement in understanding and developing treatments for this serious mental health condition.
Schizophrenia has profound effects on an individual's thoughts, emotions, and behaviors, leading to various symptoms such as hallucinations, delusions, disorganized thinking, and behavioral changes.
In this groundbreaking study, scientists at the Centre for Neuropsychiatric Genetics and Genomics (CNGG) at Cardiff University concentrated on identifying rare, impactful mutations in protein-coding genes that are notably more prevalent in individuals with schizophrenia.
The research, published in Nature Communications, pinpointed two genes, STAG1 and ZNF136, that demonstrated a strong genetic correlation with schizophrenia.
Additionally, six more genes, including SLC6A1, KLC1, PCLO, ZMYND11, BSCL2, and CGREF, showed moderate evidence of association.
The findings revealed that SLC6A1 and KLC1 are the first schizophrenia risk genes solely linked through missense variants, a specific type of mutation that modifies the amino acid sequence in proteins.
Dr. Sophie Chick, a doctoral student at Cardiff University, stated, "These findings provide valuable insights, suggesting that schizophrenia may be associated with alterations in the organization of DNA within cells and disruptions in how brain cells communicate via a neurotransmitter known as GABA."
Dr. Chick further emphasized, "This research enhances our comprehension of the intricate neurobiology underlying schizophrenia and brings us closer to advancing drug discovery and improving treatment options."
The international study evaluated genetic data from 28,898 individuals diagnosed with schizophrenia, alongside 103,041 without the disorder, and 3,444 families affected by it.
This research also reinforces the notion of shared genetic origins between schizophrenia and other neurodevelopmental disorders.
Among the newly identified genes, STAG1, SLC6A1, ZMYND11, and CGREF1 have previously been connected to conditions like autism, epilepsy, and developmental delays.
Lead author Dr. Elliott Rees from Cardiff University School of Medicine remarked, "While it has long been recognized that rare genetic variants contribute to schizophrenia, pinpointing specific genes related to these mutations has posed a significant challenge.”
Although translating these genetic findings into practical treatments is a long-term aspiration, the results present new optimism for directing drug development and creating targeted therapies in the future.
Point of View
I believe that the identification of these new genes marks a pivotal moment in mental health research, offering hope for more effective treatments for schizophrenia. This discovery could significantly impact the lives of millions and reinforce the importance of ongoing research in this field.
NationPress
30/08/2025
Frequently Asked Questions
What is schizophrenia?
Schizophrenia is a severe mental disorder that affects how a person thinks, feels, and behaves, often resulting in symptoms like hallucinations and delusions.
How do these new genes impact treatment?
The identification of these genes may guide the development of targeted therapies, leading to improved treatment options for individuals with schizophrenia.
What methods were used in the study?
The study analyzed genetic data from tens of thousands of individuals, focusing on rare mutations in protein-coding genes linked to schizophrenia.
Who conducted this research?
The research was conducted by scientists at the Centre for Neuropsychiatric Genetics and Genomics at Cardiff University.
What are the implications of this research?
The findings suggest a deeper understanding of the genetic factors contributing to schizophrenia, potentially leading to new therapeutic approaches.
