Why Do Women Have a Higher Risk of Multiple Sclerosis and Alzheimer's?
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Synopsis
A groundbreaking study reveals a gene linked to inflammation in the female brain, uncovering why women are more susceptible to Alzheimer's and multiple sclerosis. This research could pave the way for targeted treatments and offers new insights into women's health.
Key Takeaways
- Gene Kdm6a drives inflammation in the female brain.
- Women face a higher risk of multiple sclerosis and Alzheimer's.
- Inflammatory responses differ significantly between genders.
- Findings may lead to new targeted treatments for women.
- Clinical practices may need to adapt for gender-specific responses to medications.
New Delhi, Oct 16 (NationPress) Researchers in the United States have pinpointed a gene located on the X chromosome that triggers inflammation in the brains of females. This discovery sheds light on why women experience a higher prevalence of diseases like Alzheimer's and multiple sclerosis.
The research team from the University of California-Los Angeles observed that females, possessing two X chromosomes, receive a "double dose" of inflammation. This phenomenon significantly contributes to the processes of aging, as well as to the development of Alzheimer's and multiple sclerosis.
In their study utilizing a mouse model for multiple sclerosis, they identified the gene Kdm6a, which is responsible for the inflammation observed in microglia—immune cells present in the brain.
Upon deactivating Kdm6a and its related protein, the study showed a notable reduction in both multiple sclerosis-like symptoms and neuropathology in female mice. These findings are documented in the journal Science Translational Medicine.
“Women suffer from multiple sclerosis and Alzheimer's disease at rates two to three times higher than men. Additionally, approximately two-thirds of healthy women experience 'brain fog' during menopause. This research provides insights into these phenomena and hints at new treatment avenues,” explained lead author Dr. Rhonda Voskuhl, who directs the Multiple Sclerosis Programme at UCLA Health.
When the researchers genetically eliminated the gene Kdm6a in brain immune cells, the inflammatory molecules transitioned from an activated state to a resting one.
The team also conducted a pharmacological reduction of the protein produced by this gene using metformin, a commonly prescribed diabetes medication.
While these strategies showed significant results in female mice, they had minimal impact on their male counterparts, according to Voskuhl.
“This aligns with the idea that there is 'more to block' in females due to having two copies of the X-linked gene,” Voskuhl added.
“This is also the reason women are more susceptible to multiple sclerosis and Alzheimer's than men. Such findings are crucial for clinical practices; women may react differently to metformin treatment compared to men.”
Point of View
We recognize the importance of addressing gender disparities in health. This research highlights critical findings that may influence treatment approaches for women suffering from neurological conditions. It’s essential to continue exploring how biological differences impact health outcomes, ensuring that our medical practices evolve to meet the unique needs of women.
NationPress
16/10/2025
Frequently Asked Questions
What gene is linked to inflammation in the female brain?
The gene identified is Kdm6a, which has been shown to drive inflammation in microglia, the immune cells of the brain.
Why are women more affected by Alzheimer's and multiple sclerosis?
Women possess two X chromosomes, resulting in a 'double dose' of inflammation, contributing to higher rates of these diseases.
What was the significant finding regarding metformin treatment?
The study suggests that women may respond differently to metformin treatment compared to men, indicating a need for gender-specific approaches in clinical settings.
