Research Reveals Youth's Heightened Vulnerability to Nicotine Addiction

Synopsis
Key Takeaways
- Young adults are more affected by nicotine than older adults.
- Nicotine reduces movement and body temperature more in younger mice.
- Age influences drug reactions, impacting treatment development.
- Increased susceptibility may lead to higher addiction risks.
- Understanding these factors is essential for effective health policies.
New Delhi, Feb 19 (NationPress) Young adults exhibit a greater vulnerability to the effects of nicotine, as their bodies are more sensitive to this dangerous and highly addictive substance compared to middle-aged individuals, according to a recent study.
In an experiment involving mice, researchers from Pennsylvania State University in the US demonstrated that the body's reaction to drugs—both therapeutic and misused—varies with age.
They emphasized the importance of considering age when developing and prescribing nicotine treatments. The findings, published in the journal Behavioral Pharmacology, revealed that nicotine decreases the body temperature of young adult mice more rapidly and significantly impairs their movement compared to middle-aged mice.
Additionally, young adult mice, aged two months, exhibited a more pronounced response to nicotine doses proportional to their body size than their middle-aged counterparts, aged eight months.
These observations highlight how nicotine's impact evolves with age, according to the researchers.
"Individuals continue to develop and transform throughout their lives, influencing how our bodies react to medications and other substances, including nicotine. This study contributes to understanding the various factors—such as age, biological sex, and genetics—necessary for creating effective medical treatments and policies for everyone," stated Thomas Gould, Professor of Biobehavioral Health and head of the Penn State Department of Biobehavioral Health.
Both young adult and middle-aged subjects exhibited reduced movement after nicotine administration, but the young adults demonstrated a more significant decrease. This suggests that the effects of nicotine are felt more intensely by younger adults, the researchers noted.
The findings indicate that the younger an individual is, the more profound the response to nicotine. This has significant implications for both preventive messaging and for assisting young nicotine users aiming to quit.
The increased sensitivity to nicotine may also elevate the risk of developing an addiction, which can have serious health consequences, the research team concluded.