Does Fatty Liver in Pregnancy Heighten Preterm Birth Risks?
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Synopsis
A groundbreaking study reveals that pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) face a significant risk of premature birth, independent of obesity. This alarming finding emphasizes the need for close monitoring and tailored clinical guidelines for managing MASLD in expectant mothers.
Key Takeaways
- Pregnant women with MASLD have a higher risk of premature birth.
- The increased risk is independent of obesity.
- Close monitoring during pregnancy is essential.
- Specific clinical guidelines for MASLD in pregnant women are recommended.
- No increased risk of congenital malformations was observed.
New Delhi, May 9 (NationPress) Expecting mothers affected by metabolic dysfunction-associated steatotic liver disease (MASLD) face an elevated risk of premature birth, and this increased risk is not attributable to obesity, according to a recent study published on Friday.
Globally, an estimated three out of ten individuals suffer from MASLD, formerly known as non-alcoholic fatty liver disease, with common risk factors including metabolic conditions such as Type 2 diabetes and overweight or obesity.
This condition has become increasingly prevalent, particularly among women of childbearing age.
Researchers from Karolinska Institutet in Sweden examined the correlation between maternal MASLD and pregnancy outcomes.
Published in the journal eClinicalMedicine, their research indicated that women with MASLD were over three times more likely to experience premature births.
Interestingly, the risk did not escalate with the severity of MASLD and remained significant even when compared to overweight or obese women without MASLD.
“This implies that the relationship is not solely linked to a high body mass index (BMI) and that the liver disease itself may have detrimental effects,” stated Carole A. Marxer, the lead author and postdoctoral researcher at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet.
Data for the study was derived from Swedish registries, encompassing 240 births from women with MASLD and 1,140 matched births from the general population.
Women with MASLD exhibited a 63% higher likelihood of requiring a caesarean section compared to the control group, although this increased risk appears to be mitigated by high BMI, as no notable difference was observed when compared to overweight or obese women lacking fatty liver disease.
“It is crucial for pregnant women diagnosed with MASLD to receive thorough monitoring throughout their pregnancy to mitigate complications. Additionally, specific guidelines tailored for pregnant women should be incorporated into clinical recommendations for MASLD,” Marxer emphasized.
Furthermore, Jonas F. Ludvigsson, a pediatrician at Örebro University Hospital and professor at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet, noted, “We did not observe an increased risk of congenital malformations or intrauterine deaths among children born to mothers with MASLD.”
However, researchers acknowledged that the increased risk could also be influenced by other factors.
Point of View
I believe that this study sheds light on a critical issue concerning maternal health. The findings underscore the necessity for heightened awareness and proactive management of MASLD during pregnancy. We must ensure that clinical guidelines evolve to include specific recommendations for these women, as it is vital for safeguarding both maternal and neonatal health.
NationPress
21/05/2025
Frequently Asked Questions
What is metabolic dysfunction-associated steatotic liver disease (MASLD)?
MASLD is a liver condition characterized by the accumulation of fat in the liver, not due to alcohol consumption. It is often associated with metabolic disorders like obesity and Type 2 diabetes.
How does MASLD affect pregnancy outcomes?
Women with MASLD are at a significantly higher risk of experiencing premature births, and this risk persists regardless of their body mass index.
What recommendations are suggested for pregnant women with MASLD?
Pregnant women diagnosed with MASLD should be closely monitored throughout their pregnancy to minimize potential complications, with specific guidelines being developed for their care.
Are there any risks of congenital malformations associated with MASLD?
The study found no increased risk of congenital malformations or intrauterine deaths among children born to mothers with MASLD.
What steps can women take to manage MASLD during pregnancy?
Women are encouraged to maintain a healthy lifestyle, including a balanced diet and regular exercise, and to consult healthcare providers for personalized care plans.
