Can the Human Heart Regenerate Muscle Cells After a Heart Attack?
Synopsis
Key Takeaways
- Human heart can regenerate muscle cells after a heart attack.
- Study conducted by Australian researchers.
- Reveals hope for innovative heart failure treatments.
- Highlights the heart's ability to produce new cells.
- New therapies could enhance regeneration.
New Delhi, Jan 20 (NationPress) In a groundbreaking revelation, researchers in Australia have discovered that the human heart possesses the ability to regenerate muscle cells following a heart attack, igniting hopes for innovative regenerative therapies for heart failure.
The research, published in Circulation Research, indicated that while certain heart regions remain scarred after an attack, they also generate new muscle cells. This remarkable phenomenon was previously observed only in mice and is now confirmed in humans for the first time, according to Xinhua.
“Historically, we believed that once heart cells perish after a heart attack, those heart regions were permanently harmed, compromising the heart's capability to circulate blood to the body's organs,” stated Robert Hume, a research fellow at the University of Sydney and the primary author of the study.
“Our aspiration is to create therapies that can enhance the heart's inherent ability to generate new cells and restore itself following an attack,” added Hume, who also leads translational research at the Baird Institute for Applied Heart and Lung Research.
While increased mitosis (the process of cell division) after a heart attack has been noted in murine heart muscles, this is the inaugural instance of such a phenomenon being verified in humans.
The team achieved this milestone by utilizing live heart tissue samples obtained from patients undergoing bypass surgery at Australia’s Royal Prince Alfred Hospital.
“The ultimate goal is to leverage this discovery to generate new heart cells that can potentially reverse heart failure,” said Professor Sean Lal, the study's lead author and a cardiologist specialized in heart failure at the Royal Prince Alfred Hospital.
Cardiovascular disease continues to be the leading cause of mortality worldwide, with heart attacks capable of destroying one-third of the cells in the human heart. Researchers emphasize that this groundbreaking discovery lays promising groundwork for novel advancements in regenerative medicine.